Tuesday, October 20, 2009

Eleven Genetic Variations Linked To Type 2 Diabetes

From left to right, the structures of A, B and...Image via Wikipedia

Scientists and mathematicians at Michigan Technological University have come up with a couple of ways to identify certain genes that cause Type 2 Diabetes. They have identified 11 variations in genes, called single nucleotide polymorphisms, or SNP’s, that indicate a high probability of inheriting Type 2 Diabetes. In diseases such as Diabetes, there are several variations in the genes coding for the disorder. How do scientists find these variations and diagnose the disease?
Scientists have created a testing device called the Ensemble Learning Approach (ELA), which is software that detects a specific grouping of SNP’s that can be directly linked to not only Diabetes, but also other diseases as well. How is this possible when there usually are over 500,000 genes in the human genome?

Well, ELA only targets suspect dangerous areas in genes by using a complex statistical method. Testing for these potentially dangerous areas using the ELA, mathematicians at Michigan Technological University have interpreted data from 500 people in the UK with the Type 2 Diabetes and 500 without the disease. They found the 11 gene variations in the people with the disease. The team says that the ELA software can be used to trace the disease in one’s family lineage as far back as great-grandparents, and possibly farther than that if there are enough data.


Image via Wikipedia

With this knowledge of what genes are linked to disease, can it be possible for the results to help find cures for diseases in the future? It seems reasonable that with enough information from ELA testing, scientists may be able to find treatments for disorders such as Diabetes type 2 as well as Parkinson’s in the future. We will hope to see advancements in ELA technology in the future.

PowerPoint


Sources:
Images from Wikipedia
http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2
http://en.wikipedia.org/wiki/Single-nucleotide_polymorphism
http://en.wikipedia.org/wiki/Human_genome
http://en.wikipedia.org/wiki/Parkinson%27s_disease
http://www.mtu.edu/

Konstantine and Nate


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